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Cellular Therapy in Orthopedics

What is Cellular Therapy?

In the field of orthopedics, cellular therapy is widely used in general. The concept of cellular therapy is a broad concept. however, the use of cells prepared under laboratory conditions mostly includes cartilage, fibrocyte and platelets. In use, the source can be bone marrow (stem cell), Plasma (Plasma enriched platelet) or directly the cell itself. Bone marrow and plasma can be put into use in a short time after being subjected to special treatments and filtered. However, for cell production, a production time is required under special culture and laboratory conditions. In general terms, the treatment is called “cellular renewal therapy”.

Why are they doing where they were left?

Cellular therapy is applied in tissues that do not have the ability to regenerate themselves. The ability of the cartilage cell itself to proliferate is suppressed within the tissue. Therefore, it cannot compensate for the tissue loss in the cartilage. However, the cell sample can be activated outside and reproduced and transplanted to the defect area and healing is prevented with tissues that do not have the quality of cicatrix-cartilage. Thus, organ or limb function is not impaired.

How and where are these cells prepared?

We first decompose the forehead cells. This is done with various processes in the form of filtration-centrifugation and healthy cells are selected under a microscope. It is then reproduced in suitable media. This reproduction is then continued by providing a certain distribution on a skeleton that we call matrix. When the appropriate volume is obtained, the tissue is ready for delivery.

What kind of preparation is made in the region to be given?

The area where the tissue will be transferred is prepared adjacent to healthy cells, well-blooded and easy to detect. Dead cells are cleaned, space is opened up to healthy tissue and blood supply is provided.

How long does it take to fulfill its new tasks?

If the tissue is a person’s own cell, it functions as long as it maintains its vitality without entering the remodeling process, and the cartilage matrix can begin to reproduce within 24-72 hours. The attachment of the tissue will take place in a period of 3-12 weeks, depending on the region it is located in. At the end of 2 years, the tissue skeleton is completely renewed and its continuity with other neighboring cells is ensured. The situation is very different in foreign cells. If cell rejection occurs, the cells are enveloped and killed within 72 hours, leaving only the matrix left behind and leaving cells that mimic cartilage called fibrocytes..

Is it on the agenda to use it in other places?

It is possible to use it in all joints, it has come to the fore to use cellular treatment in fractures with super adhesives.

How do you think the future of treatment?

In the future, we will do all the treatments using cells. Even the nervous tissue that cannot be regenerated will be treated in this way.

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